In vitro Study on Interaction of Ketotifen Fumerate with Paracetamol
Loading...
Date
2010-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
CRP, International Islamic University Chittagong, Bangladesh
Abstract
Interaction of ketotifen fumerate and paracetamol was studied in aqueous media. The ability of interaction of ketotifen with paracetamol is dependent on pH of the solution and it has been found that ketotifen forms 1:1 complexes at different pH. The stability constants have been calculated from the Ardon’s spectrophotomeric measurements of the reaction systems. When ketotifen was interacted with paracetamol and the absorbance was determined at 300 nm the stability constants were found of -7.32 and -7.84 at pH 1.6 and 7.4 respectively.
Description
pdf
Keywords
Stability constant, Job’s method, Ardon’s mehod, Ketotifen, Paracetamol
Citation
Volume 7, December 2010, Page 49-54, Article-4