Future drug delivery technologies: benchtop to industry
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Date
2017-06
Journal Title
Journal ISSN
Volume Title
Publisher
CRP, International Islamic University Chittagong, Bangladesh
Abstract
Transmucosal buckle drug delivery system is considered as a future drug delivery technology, always assist to enhance patient compliance mainly for pediatric and geriatric community. The studies aim to develop buccal delivery for delivering a hydrophilic drug, flucloxacillin sodium, across the mucosal route. The buccal films are comprised of a bio adhesive polymer, plasticizer and drug. Optimized films were characterized by measurement of weight, length and width, hardness, thickness, surface pH, moisture content and uptake, swelling study, folding resilience, hydration and entrapment efficiency. Drug release studies were performed for different polymer-plasticizer-drug ratios. Concentration of polymer and plasticizer were influenced on the development, evaluation and release rate of flucloxacillin sodium from the buccal films. In conclusion, these studies reveal that buccal delivery of flucloxacillin sodium can be an alternative route in comparison to conventional route for patient compliance.
Description
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Keywords
Buccal delivery, Solvent casting, Drug release
Citation
Volume 14, June 2017 Article-1