Kattosh (Lasia spinosa (L.) Thwaites) an edible vegetable improve anxiety and depression in animal model

Abstract

Lasia spinosa (L.) thw is utilized in folk medication against different ailments such as diabetic, anxiety and depression. The aim of the present study was to investigate the anxiolytic and antidepression activities of hydroalcoholic extract of Lasia spinosa (HaE-LS) in mice model. This research investigated the effects of hydroalcoholic extract (HaE-LS) L. spinosa in recovery of behavioral changes through its, anxiolytic and anti-depressant impacts. The anxiolytic activity was assessed by elevated plus maze (EPM) test and hole board tests (HBT), anti-depressant effect was appraised by tail suspension tests (TST) and forced swimming test (FST). During the anxiolytic assay by elevated plus maze test, the HaE-LS significantly (p< 0.05) increased the time spent in the open arm 71.67 ± 4.70 sec at the dosages of 400 mg/kg. In HBT HaE-LS exhibited dose-dependent anxiolytic activity. In TST, mice swallowed with 400 mg/kg of HaE-LS demonstrated significant (p< 0.005) immobile time 60.33 ± 2.37 sec.In FST, the HaE-LS displayed reductions in their immobility times, which was significant 75.67 ± 2.33 sec and 61.67 ± 2.33 sec at the dosage of 200 and 400 mg/kg, respectively. Overall, the results recommend that HaE-LS could be a promising beneficial option for the treatment of anxiety and depression disorders