IIUC Journal of Science and Engineering

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Subject: search.filters.subject.Cytotoxicity

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    In vitro antimicrobial, cytotoxicity, antioxidant and In vivo analgesic activities of methanol extract of Dipterocarpus turbinatus leaves
    (Center for Research and Publication (CRP), 2024-12) Abu Sayeed, Mohammad; Ahmad, Muzammil; Kader, Shalah Uddin; Hasan, Mehedi
    The study aimed to investigate the antimicrobial, cytotoxic, antioxidant, and analgesic properties of a methanol extract of Dipterocarpus turbinatus leaves. The extract shows a moderate antimicrobial effect against the tested organisms at different concentrations (10-19 mm of zone of inhibition). The percentage of mortality was observed to increase as the dose increased. The LC50 was found to be 408.50 μg/mL which proved the plant to be a good source of novel drugs with less toxicity. It exhibits antioxidant effect revealed by increase in the percentage of scavenging assay observed with increase in concentration. The presence of reductants in MEDT was also revealed. The number of writhing which is a dose dependent shows highest number at a dose of 200 mg/kg body weight i.e., 32.83±1.25 and 28.16±1.89, 15.5±2 for 400 mg/kg of MEDT and 10 mg/kg of Diclofenac-Na respectively. At a dose 0f 200 mg/kg of MEDT, 28.51±0.560 seconds were spent licking the paw while at a dose of 400 mg/kg of MEDT, 23.60±0.545 seconds were spent licking the paw.
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    Comparative valorisation on biological activities of Leea indica, Oroxylum indicum, Mikania micranth and Smilax macrophylla as a sustainable source of bioactive ingredients
    (CRP, International Islamic University Chittagong, 2023-12) Islam, Mohammad Nazmul
    In Bangladesh, Leea indica, Oroxylum indicum, Mikania micrantha and Smilax macrophylla have been reported to have medicinal properties to treat numerous types of diseases, such as inflammation, pain, diarrhoea, skin problems and asthma. The present study designed in a comparative manner, assesses the qualitative phytochemical analysis, cytotoxic and antinociceptive activities of methanol leaves extract of L. indica (MELI), O. indicum (MEOI), M. micrantha (MEMM), and methanol extract of S. macrophylla leaves (MESMl) and stems (MESMs). The methanol extract of each plant comprises a significant quantity of secondary metabolites in the phytochemical study. At the same time, a non-significant weak to high toxicity in the brine shrimp lethality bioassay was assessed. Acetic acid and formalin-induced antinociceptive activity demonstrated highly significant (p < 0.001) dose-dependent pain reduction at a higher dose (400 mg/kg). Hence, current findings suggest that all five methanol extracts have potential antinociception effects along with weak to high cytotoxicity. Remarkably, these plants can be a successful substitute besides agri-food substances in the treatment of nociception.