IIUC Journal of Science and Engineering

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Subject: search.filters.subject.Antimicrobial

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    In vitro antimicrobial, cytotoxicity, antioxidant and In vivo analgesic activities of methanol extract of Dipterocarpus turbinatus leaves
    (Center for Research and Publication (CRP), 2024-12) Abu Sayeed, Mohammad; Ahmad, Muzammil; Kader, Shalah Uddin; Hasan, Mehedi
    The study aimed to investigate the antimicrobial, cytotoxic, antioxidant, and analgesic properties of a methanol extract of Dipterocarpus turbinatus leaves. The extract shows a moderate antimicrobial effect against the tested organisms at different concentrations (10-19 mm of zone of inhibition). The percentage of mortality was observed to increase as the dose increased. The LC50 was found to be 408.50 μg/mL which proved the plant to be a good source of novel drugs with less toxicity. It exhibits antioxidant effect revealed by increase in the percentage of scavenging assay observed with increase in concentration. The presence of reductants in MEDT was also revealed. The number of writhing which is a dose dependent shows highest number at a dose of 200 mg/kg body weight i.e., 32.83±1.25 and 28.16±1.89, 15.5±2 for 400 mg/kg of MEDT and 10 mg/kg of Diclofenac-Na respectively. At a dose 0f 200 mg/kg of MEDT, 28.51±0.560 seconds were spent licking the paw while at a dose of 400 mg/kg of MEDT, 23.60±0.545 seconds were spent licking the paw.
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    In vitro antimicrobial and antiarthritic effects of methanolic extract of Zanthoxylum rhetsa leaves
    (CRP, International Islamic University Chittagong, 2023-12) Sayeed, Mohammed Abu; Ali, Md. Sekendar; Chowdhuy, U Swe Sing; Islam, Ameerul; Ruzzama, Naiya; Muzammil Ahmad; Azad, Afrina
    The antimicrobial study of Zanthoxylum rhetsa leaves methanol extract was evaluated by the disc diffusion method against some pathogenic organisms. It exhibits the activity against almost all the test bacterial and fungal species with the zone of inhibition from mild to moderate in different concentrations- 100, 300 and 500 μg/disc where microbial species exhibits from minimum 10 to maximum 27 mm zone of inhibition. The Antiarthritic test have also done by using six concentrations for UV absorbance of test solution, product control solution, test control solution and percentage of inhibition of methanolic extract of Z. rhetsa with comparison of standard Diclofenac sodium in different concentrations like 31.75 μg/mL, 62.5 μg/mL, 125 μg/mL, 250 μg/mL, 500 μg/mL and 1000 μg/mL where different concentrations showed an increase in all the parameters that was significant from test, control and standard groups. The present study indicates that, the extract has both antibacterial and antifungal activity from mild to moderately in different concentrations and has significantly antiarthritic activities.