IIUC Journal of Science and Engineering

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Author: search.filters.author.Sayeed, Mohammed Abu

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    In vitro quality assessment of ketotifen fumarate tablets commercially available in Bangladesh
    (Center for Research and Publication (CRP), 2024-12) Sayeed, Mohammed Abu
    Quality defines the standard of a product and every company strives to achieve it, although it is often challenging. Quality of pharmaceutical products is very important for achieving the therapeutically activity of the standard drugs. This research work was aimed to investigate the quality control parameters of five brands of ketotifen that are available in the market. The five ketotifen brands were collected from the Bangladeshi local market, after which they underwent various physical parameter assessments including weight variation, hardness, friability, potency, disintegration, and acid-base degradation assessments. The brands passed the tests as no tablets crossed the ±10 % weight variation. The percentage friability of the five brands was less than 1%, hence they satisfied the standards. The disintegration time of the tablets did not exceed 5 minutes; therefore, they met the standards. All the brands showed potency ranging from 90 to 110%. In the degradation studies, no products met the USP specified limit. The average hardness of all brands did not meet the standard criterion.
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    In vitro antimicrobial and antiarthritic effects of methanolic extract of Zanthoxylum rhetsa leaves
    (CRP, International Islamic University Chittagong, 2023-12) Sayeed, Mohammed Abu; Ali, Md. Sekendar; Chowdhuy, U Swe Sing; Islam, Ameerul; Ruzzama, Naiya; Muzammil Ahmad; Azad, Afrina
    The antimicrobial study of Zanthoxylum rhetsa leaves methanol extract was evaluated by the disc diffusion method against some pathogenic organisms. It exhibits the activity against almost all the test bacterial and fungal species with the zone of inhibition from mild to moderate in different concentrations- 100, 300 and 500 μg/disc where microbial species exhibits from minimum 10 to maximum 27 mm zone of inhibition. The Antiarthritic test have also done by using six concentrations for UV absorbance of test solution, product control solution, test control solution and percentage of inhibition of methanolic extract of Z. rhetsa with comparison of standard Diclofenac sodium in different concentrations like 31.75 μg/mL, 62.5 μg/mL, 125 μg/mL, 250 μg/mL, 500 μg/mL and 1000 μg/mL where different concentrations showed an increase in all the parameters that was significant from test, control and standard groups. The present study indicates that, the extract has both antibacterial and antifungal activity from mild to moderately in different concentrations and has significantly antiarthritic activities.