IN VIVO AND IN VITRO EVALUATION OF PHARMACOLOGICAL ACTIVITIES OF Hedychium coccineum RHIZOMES EXTRACT

dc.contributor.authorNishi1, Sadia Islam
dc.contributor.authorBarua1, Niloy2
dc.contributor.authorSayeed, Mohammed
dc.contributor.authorTareq1, Abu Montakim
dc.contributor.authorMina1, Sahnaj Begum
dc.contributor.authorEmran3, Talha Bin
dc.contributor.authorDhama4, Kuldeep
dc.date.accessioned2021-09-26T08:55:21Z
dc.date.available2021-09-26T08:55:21Z
dc.date.issued2021-06-03
dc.descriptionArticleen_US
dc.description.abstractThe study reports the in vivo antidiarrheal and in vitro anthelmintic, cytotoxic, and thrombolytic activity of methanol extract of Hedychium coccineum rhizomes (MEHC). The antidiarrheal activity was determined using Castor oil-induced diarrhea and Gastrointestinal motility test in mice at the doses of 200 and 400 mg/kg body weight, whereas an aquarium worm, Tubifex tubifex, was used to determine the anthelmintic activity. The cytotoxic and thrombolytic activity of MEHC was performed by Brine shrimp lethality bioassay and clot lysis method respectively. In antidiarrheal, castor oil-induced diarrhea and gastrointestinal motility exhibited a significant reduction in diarrhea and defecation and an extremely significant inhibition in intestinal motility and peristalsis index by 200 and 400 mg/kg of MEHC. The MEHC (5, 10, and 20 mg/mL) showed a significant dose-dependent manner paralysis time and times to death in multiple comparisons to the different levamisole concentrations (0.5, 0.8, and 1 mg/mL) at in vitro anthelmintic activity. The brine shrimp lethality bioassay exhibited a weak LC50 (681.95 μg/mL; R² = 0.951) while in thrombolytic a significant percentage of clot lysis (32.70%, P < 0.05) demonstrated. The findings demonstrate that H. coccineum rhizomes could be potential sources for biological activity.en_US
dc.identifier.issn2320 – 8694
dc.identifier.urihttp://dspace.iiuc.ac.bd:8080/xmlui/handle/123456789/2820
dc.language.isoenen_US
dc.publisherDOI: http://dx.doi.org/10.18006/2021.9(3).335.342en_US
dc.subjectHedychium coccineumen_US
dc.subjectZingiberaceaeen_US
dc.subjectAntidiarrhealen_US
dc.subjectAnthelminticen_US
dc.subjectThrombolyticen_US
dc.titleIN VIVO AND IN VITRO EVALUATION OF PHARMACOLOGICAL ACTIVITIES OF Hedychium coccineum RHIZOMES EXTRACTen_US
dc.typeArticleen_US

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