Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida

dc.contributor.authorAlam, Najmul
dc.contributor.authorBanu, Naureen
dc.contributor.authorAziz, Arfin Ibn
dc.contributor.authorBarua, Niloy
dc.contributor.authorRuman, Umme
dc.contributor.authorJahan, Israt
dc.contributor.authorJahan, Farhana
dc.contributor.authorDenath, Susmita
dc.contributor.authorPaul, Arkajyoti
dc.contributor.authorUddin, Nazim
dc.contributor.authorSayeed, Mohammed Aktar
dc.contributor.authorEmran, Talha Bin
dc.contributor.authorGandara, Jesus Simal
dc.date.accessioned2021-09-26T09:19:26Z
dc.date.available2021-09-26T09:19:26Z
dc.date.issued2021-06-03
dc.description.abstractSterculia foetida, also known as jangli badam in Bangladesh, is a traditionally used plant that has pharmacological activities. A qualitative phytochemical analysis was performed to assess the metabolites in a methanolic extract of S. foetida seeds (MESF), and the cytotoxic, thrombolytic, anti-arthritics, analgesic, and antipyretic activities were examined using in vitro, in vivo, and in silico experiments. Quantitative studies were performed through gas chromatography-mass spectroscopy (GC-MS) analysis. The brine shrimp lethality bioassays and clot lysis were performed to investigate the cytotoxic and thrombolytic activities, respectively. The anti-arthritics activity was assessed using the albumin denaturation assay. Analgesic activity was determined using the acetic acidinduced writhing test and the formalin-induced paw-licking test. A molecular docking study was performed, and an online tool was used to perform ADME/T (absorption, distribution, metabolism, and excretion/toxicity) and PASS (Prediction of Activity Spectra for Substances). GC-MS analysis identified 29 compounds in MESF, consisting primarily of phenols, terpenoids, esters, and other organic compounds. MESF showed moderate cytotoxic activity against brine shrimp and significant thrombolytic and anti-arthritics activities compared with the relative standards. The extract also showed a dose-dependent and significant analgesic and antipyretic activities. Docking studies showed that 1-azuleneethanol, acetate returned the best scores for the tested enzymes. These findings suggested that MESF represents a potent source of thrombolytic, anti-arthritic, analgesic, antipyretic agents with moderate cytotoxic effects.en_US
dc.identifier.urihttp://dspace.iiuc.ac.bd:8080/xmlui/handle/123456789/2821
dc.language.isoenen_US
dc.publisherhttps://www.mdpi.com/journal/plantsen_US
dc.subjectSterculia foetida;en_US
dc.subjectGC-MS;en_US
dc.subjectcytotoxic;en_US
dc.subjectthrombolytic;en_US
dc.subjectanalgesic;en_US
dc.subjectantipyretic;en_US
dc.subjectmolecular dockingen_US
dc.titleChemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetidaen_US
dc.typeArticleen_US

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