Investigation of the Pharmacological Properties of Lepidagathis hyalina Nees through Experimental Approaches

dc.contributor.authorFahad, Fowzul Islam
dc.contributor.authorBarua, Niloy
dc.contributor.authorIslam, Md. Shafiqul
dc.contributor.authorSayem *, Al Jawad
dc.contributor.authorBarua, Koushik
dc.contributor.authorUddin, Mohammad Jamir
dc.contributor.authorUddin, Md. Nazim
dc.contributor.authorAdnan, Md.
dc.contributor.authorIslam, Mohammad Nazmul
dc.contributor.authorSayeed, Mohammed Aktar
dc.contributor.authorEmran, Talha Bin
dc.contributor.authorGandara, Jesus Simal
dc.contributor.authorEster Pagano 5
dc.contributor.authorRafandfaele Capasso 6
dc.date.accessioned2021-09-27T08:18:34Z
dc.date.available2021-09-27T08:18:34Z
dc.date.issued2021-02-25
dc.description.abstractLepidagathis hyalina Nees is used locally in Ayurvedic medicine to treat coughs and cardiovascular diseases. This study explored its pharmacological potential through in vivo and in vitro approaches for the metabolites extracted (methanolic) from the stems of L. hyalina. A qualitative phytochemical analysis revealed the presence of numerous secondary metabolites. The methanol extract of L. hyalina stems (MELHS) showed a strong antioxidative activity in the 1,1-diphenyl-2- picrylhydrazyl (DPPH) and reducing power assays, and in the quantitative (phenolic and flavonoid) assay. Clot lysis and brine shrimp lethality bioassays were applied to investigate the thrombolytic and cytotoxic activities, respectively. MELHS exhibited an expressive percentage of clot lysis (33.98%) with a moderately toxic (115.11 g/mL) effect. The in vivo anxiolytic activity was studied by an elevated plus maze test, whereas the antidepressant activity was examined by a tail suspension test and forced swimming test. During the anxiolytic evaluation, MELHS exhibited a significant dosedependent reduction of anxiety, in which the 400 mg/kg dose of the extract showed 78.77 4.42% time spent in the open arm in the elevated plus maze test. In addition, MELHS demonstrated dosedependent and significant activities in the tail suspension test and forced swimming test, whereas the 400 mg/kg dose of the extract showed 87.67 6.40% and 83.33 6.39% inhibition of immobile time, respectively. Therefore, the current study suggests that L. hyalina could be a potential source of anti-oxidative, cytotoxic, thrombolytic, anxiolytic, and antidepressant agents. Further study is needed to determine the mechanism behind the bioactivities.en_US
dc.identifier.urihttp://dspace.iiuc.ac.bd:8080/xmlui/handle/123456789/2823
dc.language.isoenen_US
dc.publisherhttps://www.mdpi.com/journal/lifeen_US
dc.subjectLepidagathis hyalina;en_US
dc.subjectantioxidants;en_US
dc.subjectcytotoxic;en_US
dc.subjectthrombolytic;en_US
dc.subjectanxiolytic;en_US
dc.subjectantidepressanten_US
dc.titleInvestigation of the Pharmacological Properties of Lepidagathis hyalina Nees through Experimental Approachesen_US
dc.typeArticleen_US

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