Evaluation of antioxidant, anti-arthritic and anthelmintic activities of methanolic leaves extract of Chaetocarpus castanocarpus (Roxb.)

Abstract

(Roxb.) leaves (MECCL). Phytochemical screenings were performed by using standard protocols. MECCL demonstrated solid free radical scavenging activity in DPPH (1, 1-diphenyl- 2-picrylhydrazyl) test, as well as total phenol and total flavonoid content were found in a quantitative assay. The topmost value of antioxidant potency (87.38%) of MECCL has exposed at 500 μg/ml concentration, whereas standard ascorbic acid reveals a 97.49% outcome at an identical concentration. However, the flavonoid and phenolic potentials of MECCL were found at 149.14± 0.084 mg QE/gm and 184.66 ± 0.064 mg GAE/gm, correspondingly. The in vitro anti-arthritic activity was appraised by protein denaturation method, whereas plant extracts proclaimed dose-dependent response working on protein denaturation method and the peak inhibition was found (60.32 ± 1.72) at 500 μg/mL concentration. MECCL also proclaimed the dose-related anthelmintic activity on aquarium worm (Tubifex tubifex) as revealed by the decreased paralyzing time and death time. So, the current research propose that Chaetocarpus castanocarpus (Roxb.) could be a better choice for managing cardiovascular disease, arthritis and helminthiasis .