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Start date: 2020Subject: search.filters.subject.Analgesic

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    In vitro antimicrobial, cytotoxicity, antioxidant and In vivo analgesic activities of methanol extract of Dipterocarpus turbinatus leaves
    (Center for Research and Publication (CRP), 2024-12) Abu Sayeed, Mohammad; Ahmad, Muzammil; Kader, Shalah Uddin; Hasan, Mehedi
    The study aimed to investigate the antimicrobial, cytotoxic, antioxidant, and analgesic properties of a methanol extract of Dipterocarpus turbinatus leaves. The extract shows a moderate antimicrobial effect against the tested organisms at different concentrations (10-19 mm of zone of inhibition). The percentage of mortality was observed to increase as the dose increased. The LC50 was found to be 408.50 μg/mL which proved the plant to be a good source of novel drugs with less toxicity. It exhibits antioxidant effect revealed by increase in the percentage of scavenging assay observed with increase in concentration. The presence of reductants in MEDT was also revealed. The number of writhing which is a dose dependent shows highest number at a dose of 200 mg/kg body weight i.e., 32.83±1.25 and 28.16±1.89, 15.5±2 for 400 mg/kg of MEDT and 10 mg/kg of Diclofenac-Na respectively. At a dose 0f 200 mg/kg of MEDT, 28.51±0.560 seconds were spent licking the paw while at a dose of 400 mg/kg of MEDT, 23.60±0.545 seconds were spent licking the paw.
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    Edible vegetable Roktoshirinchi (Achyranthes ferruginea Roxb.) ameliorates pain and inflammation in experimental animal model
    (International Islamic University Chittagong, 2023-07) Reza, A. S. M. Ali
    Achyranthes ferruginea, a plant commonly used in Bangladeshi traditional medicine, was investigated in this study to uncover new therapeutic applications. The research focused on assessing it’s in vitro anti-inflammatory properties and in vivo analgesic effects using a methanol extract. In vitro, the methanol extract of Achyranthes ferruginea was examined for its anti-inflammatory effects through membrane stabilization and protein denaturation tests using Human Red Blood Cells (HRBCs). The results indicated a moderate dose-dependent anti-inflammatory effect, with maximum inhibitions of 34.5% (protein denaturation) and 53.68% (membrane stability) at a concentration of 1000 μg/ml For in vivo assessments, Swiss albino mice were utilized, with Diclofenac Sodium as a positive control. The extract demonstrated significant dose-dependent analgesic effects in both chemically induced paw licking and writhing tests. Furthermore, molecular docking studies revealed a higher binding affinity of N-trans-feruloyl-4'-O-methyldopamine with COX-1 and COX-2 enzymes. Overall, Achyranthes ferruginea methanol extract exhibited moderate anti-inflammatory activity and robust analgesic properties, highlighting its potential therapeutic applications.