Browsing by Author "Islam, Mohammad Nazmul"

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Biological investigations of the methanol extract of Tetrastigma leucostaphylum (Dennst.) Alston ex Mabb. (Vitaceae): In vivo and in vitro approach
(www.bsmiab.org, 2020-06-14) Rudra, Sajib; Sawon, Solaman Uddin; Emon, Nazim Uddin; Alam, Safaet; Tareq, Syed Mohammed; Islam, Mohammad Nazmul; Uddin, Md. Rokib; Md Sazid, Abdullah; Hasbe, Abu Nazer; Shakil, Mohammad; Sakib, Shahenur Alam; Sayeed, Mohammed Aktar
Tetrastigma leucostaphylum (Family: Vitaceae) is popular for its medicinal value in Bangladeshi tribal communities. This study aims to investigate several pharmacological values of methanol extract of T. leucostaphylum (METL). In vivo analgesic and anti-inflammatory researches have been implemented by using acetic acid-induced writhing and formalin-induced paw licking test protocols in mice. Furthermore, in vitro thrombolytic and anthelmintic studies have been performed by following the blood clot lysis method and nematode mortality measurement method. In the in vivo study, METL did not minimize the acetic acid-induced writhes prominently but significantly attenuate both the peripheral and inflammatory pain in mice in a dose-dependent manner. In early and late phase, METL 400 (mg/kg, b.w; p.o) showed 39.63 % and 48.73 % paw licking inhibition. Again, METL (100 μL) reflected 56.62 % clot lysis in thrombolytic research. Besides, METL causes the death of nematodes in a dose-dependent manner. The bioassay of the methanol extract of T. leucostaphylum justified the analgesic, anti-inflammatory, thrombolytic and anthelmintic activities of the crude extract and finally suggests the test extract as a wellspring of anti-inflammatory, thrombolytic and anthelmintic agents as a crude drug source.
Comparative valorisation on biological activities of Leea indica, Oroxylum indicum, Mikania micranth and Smilax macrophylla as a sustainable source of bioactive ingredients
(CRP, International Islamic University Chittagong, 2023-12) Islam, Mohammad Nazmul
In Bangladesh, Leea indica, Oroxylum indicum, Mikania micrantha and Smilax macrophylla have been reported to have medicinal properties to treat numerous types of diseases, such as inflammation, pain, diarrhoea, skin problems and asthma. The present study designed in a comparative manner, assesses the qualitative phytochemical analysis, cytotoxic and antinociceptive activities of methanol leaves extract of L. indica (MELI), O. indicum (MEOI), M. micrantha (MEMM), and methanol extract of S. macrophylla leaves (MESMl) and stems (MESMs). The methanol extract of each plant comprises a significant quantity of secondary metabolites in the phytochemical study. At the same time, a non-significant weak to high toxicity in the brine shrimp lethality bioassay was assessed. Acetic acid and formalin-induced antinociceptive activity demonstrated highly significant (p < 0.001) dose-dependent pain reduction at a higher dose (400 mg/kg). Hence, current findings suggest that all five methanol extracts have potential antinociception effects along with weak to high cytotoxicity. Remarkably, these plants can be a successful substitute besides agri-food substances in the treatment of nociception.
Investigation of the Pharmacological Properties of Lepidagathis hyalina Nees through Experimental Approaches
(https://www.mdpi.com/journal/life, 2021-02-25) Fahad, Fowzul Islam; Barua, Niloy; Islam, Md. Shafiqul; Sayem *, Al Jawad; Barua, Koushik; Uddin, Mohammad Jamir; Uddin, Md. Nazim; Adnan, Md.; Islam, Mohammad Nazmul; Sayeed, Mohammed Aktar; Emran, Talha Bin; Gandara, Jesus Simal; Ester Pagano 5; Rafandfaele Capasso 6
Lepidagathis hyalina Nees is used locally in Ayurvedic medicine to treat coughs and cardiovascular diseases. This study explored its pharmacological potential through in vivo and in vitro approaches for the metabolites extracted (methanolic) from the stems of L. hyalina. A qualitative phytochemical analysis revealed the presence of numerous secondary metabolites. The methanol extract of L. hyalina stems (MELHS) showed a strong antioxidative activity in the 1,1-diphenyl-2- picrylhydrazyl (DPPH) and reducing power assays, and in the quantitative (phenolic and flavonoid) assay. Clot lysis and brine shrimp lethality bioassays were applied to investigate the thrombolytic and cytotoxic activities, respectively. MELHS exhibited an expressive percentage of clot lysis (33.98%) with a moderately toxic (115.11 g/mL) effect. The in vivo anxiolytic activity was studied by an elevated plus maze test, whereas the antidepressant activity was examined by a tail suspension test and forced swimming test. During the anxiolytic evaluation, MELHS exhibited a significant dosedependent reduction of anxiety, in which the 400 mg/kg dose of the extract showed 78.77 4.42% time spent in the open arm in the elevated plus maze test. In addition, MELHS demonstrated dosedependent and significant activities in the tail suspension test and forced swimming test, whereas the 400 mg/kg dose of the extract showed 87.67 6.40% and 83.33 6.39% inhibition of immobile time, respectively. Therefore, the current study suggests that L. hyalina could be a potential source of anti-oxidative, cytotoxic, thrombolytic, anxiolytic, and antidepressant agents. Further study is needed to determine the mechanism behind the bioactivities.