Browsing by Author "Chowdhury, Kazi Ashfak Ahmed"

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    In vitro drug-drug interaction study between Ranitidine Hydrochloride and Bisoprolol fumarate
    (International Islamic University Chittagong, 2023-07) Chowdhury, Kazi Ashfak Ahmed
    The current study's objective is to assess the pharmacological interactions between Bisoprolol fumarate and Ranitidine hydrochloride using in vitro model. Using the Job's approach and Ardon's method, a spectral observation research, and the thin layer chromatography method, interactions between bisoprolol fumarate and ranitidine hydrochloride were assessed. UV-VIS spectrophotometers were used for spectral observation in both acidic and basic pH conditions. Different spectra from the individuals and 1:1, 1:2, and 2:1 complexes were obtained in the UV-VIS spectrophotometer. The drug complexes produced a distinct spectrum than its pure component. When Ranitidine hydrochloride is combined with Bisoprolol fumarate at a 1:1 ratio, the spectra suddenly alters as a result of interaction. The stability constant values at various levels of pH (1.2, 2.0, 3.0, 5.5, and 6.4) determined by the Ardon's plots are 0.896, 1.612, 1.200, 1.36, and 0.294. According to the stability constant values, Bisoprolol fumarate and Ranitidine hydrochloride interact in a moderately stable manner. Because of this, the complex displayed fluctuating activity during the test.
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    In vitro, in vivo and in silico drugdrug interaction study between Vildagliptin and Bisoprolol fumarate
    (CRP, International Islamic University Chittagong, Bangladesh, 2017-06) Chowdhury, Kazi Ashfak Ahmed; Kabir, Mohammad Shah Hafez; Hossain, Mohammed Munawar; Chowdhury, Tanvir Ahmad; Chakrabarty, Nishan
    Aim of the present study is to evaluate the in vitro, in vivo and in silico drug-drug interaction between Vildagliptin and Bisoprolol fumarate. Interaction between Vildagliptin and Bisoprolol fumarate has been studied in a system of water at a fixed 370C at pH 1.0, 3.0 and 6.8 by using spectral observation, Job’s method of continuous variation, Ardon’s method. In silico complexation was measured by NMR prediction and DDI-CPI analysis. From spectrophotometric study, Vildagliptin and Bisoprolol fumarate give different spectra when Vildagliptin mixed with Bisoprolol fumarate in 1:1 mixture, intensity of spectra of Vildagliptin transform surprisingly due to interaction. The jobs plot was attained by plotting absorbance difference (D) against the mole fraction of the each drug at pH 1, 3, and 6.8. Vildagliptin moderate for 1:1 mixture with Bisoprolol fumarate and slightly lower spectra indicate the formation of 1:1 mixture of Vildagliptin with Bisoprolol fumarate. The value of stability constant for the drug-drug system at pH 1.0, 3.0 and 6.8 are 1.875 0.7778 and 1.2000 respectively. From the IR report it also proved that Vildagliptin and Bisoprolol fumarate produced interaction. In this OGTT test at 1:1, 1:2 and 2:1 complex blood glucose level decrease compared to Vildagliptin. Because when drug-drug interaction happened, then drug cannot exhibit its main activity. That’s why in this test complex showed different activity. In in silico methods, results showed that the drugs interact with each other. So, a careful concern is desired during simultaneous administration of Vildagliptin with Bisoprolol fumarate